A Comparative Study on Efficacy of Norethisterone and Medroxyprogestrone in the Management of Dysfunctional Uterine Bleeding: A Prospective Observational Study

Mohammad Irfan Abdul Kader^1* , V. Karthikeyan¹ and Sabitha J²

¹Department of Pharmacy Practice, Grace College of Pharmacy, Kodunthirapully, Palakkad, Kerala- India

²Gynaecologist-Obstetrician, Paalana Institute of Medical Sciences, Palakkad, Kerala- India

Corresponding Author E-mail:muhammedirfanea@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3115

ABSTRACT: Background: Dysfunctional uterine bleeding (DUB) is defined as bleeding from the uterine corpus that is abnormal in regularity, volume, frequency, or duration and occurs in the absence of pregnancy. Methylprogesterone (MPA) and Norethisterone (NE) are a sort of female hormone (progestin).To cure dysfunctional uterine bleeding, this study sought to determine how MPA and NE worked. Materials and Procedures Over three months, a prospective observational study was conducted at a hospital in Palakkad. The usefulness of MPA and NE is analyzed by using the PBAC score method. Using Microsoft Excel 2007, the cases were entered, and descriptive statistical analysis was then performed. Results and Discussion There were 71 respondents in this study, with ages ranging from 18 to 35 and older. 32 of the 71 people received MPA, whereas 39 of them acquired NE. DUB was much more prevalent in women over 35 (NE-56.4% and MPA-75%). DUB is usually seen in overweight individuals (NE: 56.4%; MPA: 50.). The PBAC score dropped after both medications were administered. Norethisterone is more effective than either of the drugs, as per this study.

KEYWORDS: Dysfunctional Uterine Bleeding (DUB); Medroxyprogesterone (MPA); Norethisterone (NE); Pictorial Blood Assessment Chart (PBAC)

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