Antioxidant Potential of Cordyceps militaris Mycelium: A Comparative Analysis of Methanol and Aqueous Extracts

Niketan Deshmukh^1* and Bhaskaran Lakshmi²

¹L J School of Applied Sciences, L J University, Ahmedabad, India.

²Department of Biotechnology, Kadi Sarva Vishwavidyalaya, Gandhinagar, India.

Corresponding Author E-mail: deshmukhniketan@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3194

ABSTRACT: Reactive oxygen species (ROS) are the metabolic byproducts of various biochemical processes of the cell. However, if the production of ROS is significantly higher compared to the cell's defence mechanism, it results in oxidative stress. Accumulation of ROS and subsequent oxidative stress can lead to a range of harmful effects on the cell, including cellular damage, inflammation, and disruptions in normal cellular functions. These effects can ultimately contribute to the development of numerous health conditions. To counteract this, it is important to supplement the body with natural antioxidants. The medicinal mushroom Cordyceps militaris, has been used for centuries for its potential health benefits and has been shown to possess antioxidant capabilities. The presented study evaluates and compares the total antioxidant capacity of two mycelium extracts of Cordyceps militaris made from methanol and water based on multiple assays. The investigation further noted that the aqueous extract exhibited greater phenolic content with a concentration of 8.50 mg of GAE/g. In contrast, the methanol extract showed a higher flavonoid content of 7.13 mg of CAE/g. The study's findings revealed that methanol and aqueous extract possess antioxidant capability that can neutralize ROS and help reduce oxidative stress.

KEYWORDS: Antioxidant; Cordyceps militaris; Oxidative stress; ROS; Reducing power

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