Formulation and Evaluation of Biopolymer Incorporated Nanogel of Nabumetone

Vrushali R. Jadhav^1* and Kiran B. Erande²

¹Department of Pharmaceutics, M.G.V’s Pharmacy College Panchavati, Nashik, Maharashtra, Affiliated to Savitribai Phule Pune University, Maharashtra, India.

²Department of Pharmaceutics, M.G.V’s S.P.H. College of Pharmacy, Malegaon Camp, Affiliated to Savitribai Phule Pune University, Maharashtra, India.

Corresponding Author E-mail: v.p.gotise10@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3187

ABSTRACT: The objective of this research was to improve the solubilization, dissolution rate, and thereby anti-inflammatory activity of the BCS class II drug Nabumetone (NSAID). A solid dispersion (SD) approach with Gelucire 50/13 was used to enhance the solubility. Microwave-induced fusion method was used for the development of SD, as it demonstrated a remarkable increase in the solubility and dissolution rate of pure drugs when compared to traditional solid dispersions. A number of parameters of the SD were evaluated in vitro, including solubility, dissolution, and Fourier Transformed Infrared Spectra obtained (FT-IR). The rate of dissolution was inclined to betterment with the drug: polymer ratio 1:0.5 showing drug release 99.60 ± 29. The objective of the work was to evolve a Nanogel for topical delivery of Nabumetone. The emulsification-diffusion method was used to create nanogel using the polymers Carbopol-940, Gelucire-50/13, and triethanolamine as gelling agents. Chitosan was added to the formulation as a biopolymer. Menthol was employed as a penetration enhancer. Using the spontaneous emulsification-diffusion method, six distinct formulations of Nabumetone-loaded Nanogel were successfully created and evaluated for particle size, zeta potential, thermodynamic stability, and rheology study. Using a cellophane membrane, the gels were examined for diffusion study further, and drug content, viscosity, spreadability, pH, and clarity were accessed. The formulation F4 batch had the best in-vitro drug release profile, with a 96.04% release rate over 270 minutes. Optimized gel F4 underwent a skin irritation study on Wistar rats and passed the test. The topical application of Nabumetone as Nanogel proved to be an effective approach to drug delivery.

KEYWORDS: Biopolymer; Cellophane membrane; Chitosan; Nabumetone; Nanogel; Solid dispersion

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