A Study on the Effectiveness of Emperical Therapy of Antibiotics in Infective Diabetic Patient

Resmi Rajan^1*, Pooja Darsan¹, Sophy CT¹, Muhammad Ameen¹, Thangamani S², and Kiran DR³

¹Department of Pharmacy Practice, Grace College of Pharmacy, Palakkad, Kerala, India.

²Karuna Medical College Hospital, Palakkad, Kerala, India.

Corresponding Author E-mail: reshmi12rajan@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3189

ABSTRACT: Background: Diabetes mellitus is a known risk factor for certain infectious diseases such as skin, mucus membrane, soft tissue, urinary tract, respiratory tract and surgical or hospital associated infections. In elderly patients initial antibiotic therapy for diabetic infection is empirical. To study the efficacy of empirical antibiotic therapy is significant to ensure the potency of the given therapy. Objective: The study was aimed to determine the effectiveness of empirical antibiotic therapy in infective Diabetes Mellitus patients. Method: A Prospective observational study, conducted in inpatients who were admitted in General medicine and surgery Department. The effectiveness of antibiotics was evaluated by parameters like the length of stay, adjustment, discontinued, modified, antibiotic days, antibiotic course and treatment period. Result: There is no significant differences between sex and occurrence of infections showed sex is an independent factor for infection and age, co-morbidities, uncontrolled diabetes had the statistically significant (p<0.01) association with occurrence of infections. The empirical therapy was found to be effective choice of treatment in GI tract infections patients and taking empirical therapy showed effective outcome without adjustment and modification and the 65% patients had < 5 days of length of stay who were treated for diabetic foot ulcer followed by GI infections, UTIs and RTIs. Conclusion: The efficacy of the empirical antibiotic therapy was more effective in patients with GI infections as per modified and discontinuation and as per the < 5 days of length of hospital stay   empirical antibiotics are effective in patients with Diabetic foot infections.

KEYWORDS: Diabetes Mellitus; Efficacy; Empirical therapy; Infections

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