A Comprehensive Review on Nanoplex Nanotechnology Strategies

Patil Rushikesh^* , Salve Devadatta, Garale Bharati, Shewalkar Ganesh and Borse Laxmikant

Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India.

Corresponding Author E-mail: rush1341998@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3220

ABSTRACT: One strategy used to get around the problems with conventional medication delivery systems is the use of nanotechnology based on the creation and growth of nanostructures. The newest development in nanotechnology is the creation of Nanoplex. A polyelectrolyte with an oppositely charged drug nanoparticle forms a complex known as a nanoplex. Both cationic and anionic medicines combine with polyelectrolytes that have opposing charges to produce complexes. The yield of Nanoplex is higher and the complexation efficiency is better when compared to other nanostructures. Additionally, nanoplex are simpler to make. Using scanning electron microscopy, differential scanning calorimetry, X-ray diffraction, and dialysis investigations, the production yield, complexation efficiency, drug loading, particle size, and zeta potential of nanoplex formulation are all evaluated. Nanoplex have a wide range of uses in various domains, including cancer treatment, medication delivery to the brain, drug delivery via genes, and drug delivery via proteins and peptides.

KEYWORDS: Application; Evaluation; Nanotechnology; Nanoplex; Mechanism

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