Impact of Gut Microbiome Dynamics on Epidermal Health  

Rutuja Nerurkar, Sara A. Khan* and Nupur Mehrotra

Department of Biochemistry, SVKM’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (Autonomous) Affiliated to University of Mumbai India.

Corresponding Author E-mail: sara.khan@mithibai.ac.in

ABSTRACT: The trillions of bacteria that reside on and inside the body constitute the human microbiome, which is essential to maintaining host health. The gut microbiome is one of these microbial communities that has attracted a lot of attention due to its effects on the skin and other physiological systems. An extensive synopsis of the complex connection between gut microbiota and epidermal health is given in this review. There are ways in which the gut microbiota influences the health of the epidermis. It has been demonstrated that gut microbe-produced metabolites, such as vitamins, secondary metabolites, and short-chain fatty acids, affect skin barrier function and immune response modulation. Furthermore, the complex interaction of immunological signalling pathways, which govern communication between the gut and skin, regulates the gut-skin axis. Rosacea, psoriasis, eczema and other dermatological disorders are related to dysbiosis of the gut microbiome. Gaining knowledge of mechanisms underlying this relationship could be extremely beneficial for the creation of novel treatment approaches targeted at enhancing health and treating or preventing a range of dermatological disorders. In order to maintain optimal epidermal health, future research endeavours should concentrate on clarifying the precise microbial taxa and metabolites that are essential to this complex interplay in gut-skin axis.

KEYWORDS: Dysbiosis; Epidermal Health; Gut-Skin Axis; Gut Microbiome; Probiotics

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