State of Adenosine Deaminase in Patients with Dyslipidemia

Amit Kumar Yadav¹, Saba Khan¹ , Shubhra Chowdhry², Rohit Kumar Srivastava³, Roshan Alam¹and Mohammad Mustufa Khan^4*

¹Department of Biochemistry, Integral Institute of Medical Sciences and Research (IIMSR), Integral University, Lucknow, Uttar Pradesh, India.

²Dr. KNS Memorial Institute of Medical Sciences, Barabanki, Uttar Pradesh, India.

³Department of Paramedical Sciences, Mahayogi Gorakhnath University, Gorakhpur, Uttar Pradesh, India.

⁴Department of Basic Medical Sciences,  Integral Institute of Allied Health Sciences & Research (IIAHSR), Integral University, Lucknow, Uttar Pradesh, India

Corresponding Author E-mail: mustufakhan@iul.ac.in

DOI : http://dx.doi.org/10.13005/bbra/3292

ABSTRACT: Background: Dyslipidemia is becoming more common across all age groups mainly in young individuals because of imbalanced diets, low physical activity, and sedentary work culture. Several studies reported that elevated serum adenosine deaminase activity was associated with dyslipidemia, but the results were not consistent. Aim: It is aimed to correlate adenosine deaminase and lipid profile parameters in patients with dyslipidemia. Material and Methods: In this case-control study, a total of 60 subjects (30 diagnosed dyslipidemia patients and 30 age and gender-matched healthy individuals) were enrolled. Serum lipid profile parameters and adenosine deaminase levels were estimated in each subject. Results: The mean levels of lipid profiles, mainly triacylglycerol (TG), low-density lipoprotein-cholesterol (LDL-C), and adenosine deaminase, were found to be significantly high, while high-density lipoprotein-cholesterol (HDL-C) was found significantly low in cases than controls (p <0.001). adenosine deaminase has not shown any significant correlation with lipid profile parameters in patients with dyslipidemia and controls. Conclusion: The result showed that the serum adenosine deaminase and serum lipid profile levels were altered in patients with dyslipidemia.

KEYWORDS: Adenosine; Adenosine Deaminase; Case-Control Study; Dyslipidemia; Lipid Profile

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