Assessment of the Dermal Toxicity of Hydnocarpus wightiana Seeds Extract in Experimental Rats

Alankar Shrivastav^1* , Deepali Singh¹ , Deepak Singh Chaudhary¹ , Navneet Verma¹ and Arun Kumar Mishra²

¹Pharmacy Academy, IFTM University, Moradabad, U. P., India

²Sahu Onkar Saran School of Pharmacy, IFTM University, Moradabad, U. P., India.

Corresponding Author E-mail:alankar1994.ss@gmail.com

DOI : http://dx.doi.org/10.13005/bbra/3282

ABSTRACT: This investigation aims to determine the dermal safety dose range for the entire Hydnocarpus wightiana plant. The acute and subacute skin toxicity investigations were evaluated using the OECD criteria 402 and 410. In the acute dermal toxicity study, the extract dosages (2000 and 5000 mg/kg) were topically given in single doses. The overall behaviour, adverse effects, and death were noted for up to 72 hours. Subsequently, in sub-acute dermal research, the various concentrations of the extract were topically given at doses of 500, 1000, and 2000 mg/kg for 28 days, and any changes were recorded. In the two groups (i.e., 2000 and 5000 mg/kg extract treatment groups), no significant behavioural alterations, sleepiness, or drowsiness were seen, and only mild sedation and lethargy were noted. Overall, there were no discernible poisoning signs or symptoms. Giving extracts (2000 mg/kg) improved the liver function parameters considerably. It was discovered that no signs were observed on the dermal application of the extract.

KEYWORDS: Acute toxicity study; Dermal Toxicity; Ethanolic extract of Hydnocarpus wightiana (EEHW); Hydnocarpus wightiana; Sub-acute toxicity study

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