Advancements in Ovarian Cancer Research: Targeting DNA Repair Mechanisms and the Role of DNA Polymerase β Inhibitors

Anutosh Patra¹, Abhishek Samanta², Anindita Chakraborty³ , Nandan Bhattacharyya^4*and Anutosh Patra¹

¹Department of Physiology, PanskuraBanamaliCollege(Autonomous), P.O.-Panskura R.S., West Bengal, India

²Department of Zoology, PanskuraBanamali College, P.O., Panskura R.S., West Bengal, India.

³Department of Stress biology, UGC DAE, Consortium for Scientific Research, Kolkata Centre, Sector III, LB-8, Bidhan Nagar, Kolkata, West Bangal, India.

⁴Department of Biotechnology, PanskuraBanamali College (Autonomous), P.O.-Panskura R.S., West Bengal, India

Corresponding Author E-mail: bhattacharyya_nandan@rediffmail.com

ABSTRACT: Background: Exposure to mutagens causes DNA damage, which, if not repaired properly, can lead to diseases like cancer. Ovarian cancer is a major concern for women globally, including in India, as it is often diagnosed at an advanced stage, making treatment more challenging. Recent research implicates DNA repair proteins like DNA polymerase β (Pol β) in cancer development, emphasising the need to understand these pathways for targeted therapy. This study uses bibliometric analysis to explore ovarian cancer research and DNA repair pathways, providing insights for future research and treatment. Materials and Methods: Data from 37,539 articles related to cancer, ovarian cancer, DNA polymerase β, DNA repair pathways, and inhibitors were analysed from the Dimensions database. Publication distribution, national cooperation, leading authors, and research trends were examined. Results: Variations in publication distribution were observed across journals, with notable contributions from countries like Germany, Canada, and the Netherlands. Prolific authors and institutions were identified, shedding light on the global academic landscape. Co-occurrence analysis revealed thematic clusters, including pathophysiology, cancer risk associations, therapeutic targets, and genomic research. Conclusion: This bibliometric analysis offers valuable insights into ovarian cancer research and DNA repair pathways. It highlights the importance of targeting DNA repair mechanisms in cancer therapy and suggests opportunities for collaboration and personalised medicine. Identifying key trends and future directions aids in advancing our understanding and treatment of ovarian cancer, aiming to improve patient outcomes.

KEYWORDS: Bibliometric analysis; Cancer therapy; DNA polymerase beta; DNA repair pathways; DNA polymerase beta inhibitors; Ovarian cancer

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