Molecular Docking, Synthesis and In vivo Assessment of New Phenothiazines as Inhibitors of Anxiety

Pooja Saini^*, Sushil Kumarand Swatantr Bahadur Singh

School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.

Corresponding Author E-mail: poojasaini0087@gmail.com

ABSTRACT: Background: Heterocylics are the backbone of the medicinal chemistry. They played very imperative role in the discovery of new lead molecules. Phenothiazine is one of them and it has many biological activities as well. This article proposed the design and synthesis of new phenothiazine derivatives. Aim: This work includes the preparation of some new Schiff bases of phenothiazine. The synthetic scheme includes development of series of 1-(10H-phenothiazin-10-yl)-2-(4-((phenylimino)methyl) phenoxy) ethan-1-one (D1-D10). Objective: This work aims to design some new phenothiazine molecules. Phenothiazine is main heterocyclic moiety of this work to perform their computational study and to evaluate the prepared molecules as anxiolytic agents. Result:  All the derivatives was synthesized in the laboratory and characterized by applying different parameters. These parameters include melting point, solubility, R_f value, spectroscopic analysis like IR spectroscopy and 1H-NMR spectroscopy. Some software was used to dock the derivatives and to perform the computational studies. Conclusion: The synthesized compounds were screened for anti-anxiety activity and elevated plus maze method was incorporated to perform the activity. Statistical analysis of the prepared derivatives was done followed by one way ANOVA dunnett’s test. Among them, some derivatives showed potent activity and some showed moderate activity against anxiety.

KEYWORDS: Anti-anxiety activity; Autodock Vina; Chalcones; Chem Draw; Computational studies; Phenothiazine

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