A Comprehensive Review on the Role of Collagen in Health and Disease

Nipun Saravanan Pillai, Sara Anees Khan*, Nupur Mehrotra and Kaustubh Jadhav

Department of Biochemistry, SVKM’s Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Economics (EMPOWERED AUTONOMOUS) Affiliated to University of Mumbai, India.

Corresponding Author E-mail: sara.khan@mithibai.ac.in

DOI : http://dx.doi.org/10.13005/bbra/3307

ABSTRACT: The most prevalent protein in the human body, collagen is essential for preserving the structural soundness and functionality of different tissues. It is an essential part of connective tissues, which include skin, cartilage, bones, tendons, and ligaments. It also plays a key role in wound healing, cell signaling, and tissue repair. The many functions of collagen in human health and its connections to different illnesses are examined in this overview. It looks at the biochemical and structural characteristics of the many forms of collagen, the processes by which collagen is synthesized and broken down, and how imbalances can result in diseases including cardiovascular problems, fibrosis, osteoarthritis, and skin aging. There is also discussion of new treatment options, such as supplements, collagen-based biomaterials, and regenerative medicine techniques. New treatments targeted at promoting tissue repair, boosting quality of life, and avoiding collagen-related illnesses may be made possible by a better understanding of the many roles that collagen plays in both health and disease.

KEYWORDS: Collagen; Joint health; Skin elasticity; Wound healing;  Therapeutic applications

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