Volume 12, number 1
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Interleukin-1 β Gene polymorphisms in Iranian Patients with Uterine Fibroid, A Case- Control Study

Fatemeh Taghizade Mortezaee1, Morteza Hashemzadeh Chaleshtori1, Effat Farrokhi1, Soleiman Kheiri2, Laleh Shariati3, Mohammad Amin Tabatabaiefar1,4 and Sepideh Miraj5*

1Cellular and Molecular Research Center, Shahrekord University of Medical Sciences,Shahrekord, Iran. 2Clinical Biochemistry Research Center, Shahrekord University of Medical Sciences,Shahrekord, Iran. 3Department of Molecular Medicine, School of Advanced Medical Technologies, Tehran University of Medical Sciences, Tehran, Iran. 4Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 5Deparmment of Obstetrics of Gynecology,Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.

ABSTRACT: Uterine leiomyoma (UL) or fibroid is the most common estrogen- dependent tumor of the reproductive system. Almost a quarter of women at reproductive age are affected with this benign tumor. The purpose of the present study was to investigate the possible association of IL-1β-511and IL-1β 3954 polymorphisms with UL in the women of Charmahal and Bakhtiari province of Iran. Totally, 276 patients with UL and 157 healthy control women were studied. The genetic polymorphisms for IL-1β-511and IL-1β 3954 were analyzed by PCR-RFLP method. The results were analyzed with SPSS software using β² test. The TC genotypes of the IL-1β -511C/T polymorphism showed a decreased risk of UL (OR = 0.232, P = 0.01, 95 % CI = 0.11 – 0.48). A significant difference was found for the C allele frequencies of the IL-1 β -511 C>T polymorphism between the two groups (OR = 0.232, P = 0.01, 95 % CI = 0.11 – 0.48). However, no significant difference was found for the IL-1 â -3954 polymorphism between the two groups. Our findings indicated that IL-1 â -511C>T promoter polymorphism affects the risk of UL in the women of our study and this polymorphism might be involved in the pathogens of this disease.

KEYWORDS: Leiomyoma; polymorphism; IL-1β; Iran

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Mortezaee F. T, Chaleshtori M. H, Farrokhi E, Kheiri S, Shariati L, Tabatabaiefar M. A, Miraj S. Interleukin-1 β Gene polymorphisms in Iranian Patients with Uterine Fibroid, A Case- Control Study. Biosci Biotech Res Asia 2015;12(1)
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Mortezaee F. T, Chaleshtori M. H, Farrokhi E, Kheiri S, Shariati L, Tabatabaiefar M. A, Miraj S. Interleukin-1 β Gene polymorphisms in Iranian Patients with Uterine Fibroid, A Case- Control Study. Biosci Biotech Res Asia 2015;12(1). Available from: https://www.biotech-asia.org/?p=5651>

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