Design and in-vitro evaluation of Lisinopril transdermal patches containing Ethylcellusose-povidone as film formers

B. G. Desai¹, A. R. Annamalai*², B. M. Dinesh¹. and K. S. Raghu¹

¹K. L. E. Society’s College of Pharmacy, II block, Rajajinagr, Bangalore - 560 010 (India) ²Anamalai university, Annamalai nagar, Chidambaram, Tamilnadu (India)

ABSTRACT: The Matrix type TDDS of Lisinopril were prepared using different ratios of Ethyl cellulose (EC): Poly vinylpyrrolidone (PVP) (3:1, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent evaporation technique. Physicochemical parameters were characterized and dissolution studies of the formulated films were performed. In addition solubility studies at various pH, partition coefficient in octanol/water system, flux and enhancement ratio were also evaluated. In-vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20%PEG 400 in normal saline. Permeation studies illustrated, 4% Hyaluronidase enzyme was a good enhancer. The prepared films were subjected to SEM and FTIR spectral analysis. Higuchi and Peppas model were used for optimizing the formulation.

KEYWORDS: Lisinopril;Transdermal Patches; PVP; EC; Permeability Study; Chemical enhancers; Optimization

[ HTML Full Text]