Hypoglycemic and metabolic activity of aqueous extract of Morus alba in streptozotocin-diabetic rats

Mosaad A. M. Abou-Seif and EL-Sayed M. Kamel*

Biochemistry and Pharmacology Departments, Faculty of Medicine, Seventh of October University, Misuratah (Libya)

ABSTRACT: Diabetes mellitus (DM) is a metabolic disorder characterized by absolute or relative deficiencies in insulin secretion and/or insulin action associated with chronic hyperglycemia. Clinical research has confirmed the efficacy of several plant extracts in the amelioration of diabetic status. There for the possible hypoglycemic activity of the aqueous extract of morus alba was investigated in streptozotocin (STZ)- induced diabetic rats. A single dose of STZ( 60 mg./kg. B.W) produced a decrease in insulin secretion , hyperglycemia .,decrease hepatic glycogen content, hepatic glucose oxidation, were as hepatic glucose 6- phosphatase ( gluconeogenesis ) activity was increase an aqueous extract of mours alba ( 200 mg./kg. ) or glicalzide ( 100mg./kg) was administer orally once dally for two weeks to STZ - induced diabetic rats ameliorated hyperglycemia and restored the metabolic enzymes of glucose to the normal values in the liver of STZ - treated rats .In addition the administration of mours alba induce the secretion of insulin from rat pancreas. The effect of produced by morus alba extract were found to be comparable with that of glicalizde. The present results suggested that the morus alba extract could be used as ant diabetic adjuvant in treatment of DM. This may be related to its induction of insulin secretion.

KEYWORDS: Morns alba; streptozotocin; insulin; glucose; metabolic enzymes of glucose.

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