The Inhibitory Effect of Itraconazole on Atherosclerosis in Hyperlipidemic Rabbits

Pourahmadi Mohammad¹, Feily Amir², Akbarnezhad Dorna³ and Kargar Jahromi Hossein⁴

¹Department of Anatomy, Jahrom University of Medical Sciences, Jahrom, Iran. ²Department of Dermatology, Jahrom University of Medical Sciences, Jahrom, Iran. ³Department of Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran. ⁴Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

ABSTRACT: Atherosclerosis is a chronic inflammatory disease of the great vessels. The drug Itraconazole, with a full antifungal range has the following important properties: anti-inflammatory feature, its inhibitory effect on the activity of 5-lipoxygenase and Chemotaxis of T-cell and the production of leukotriene, its effect on stopping VEGF, its decreasing effect on LDL -C and its increasing effect on the HDL -C and IL-10. 40 rabbits were divided into 4 equal groups. The day before the experiment the animals were bled and then the first group was fed standard food, the second group was fed a high-cholesteroldiet, the third group was fed standard food and Itraconazole and the fourth group was fed a high-cholesterol diet and Itraconazole, at the end of the twelfth week the animals were bled and information was reviewed. Significant reduction in serum levels of TC, TG and LDL-C and a significant increase in HDL-C in the fourth group compared to the second group at the end of the experiment, indicates the effectiveness of this drug on the adjustment mode of Dyslipidemia caused by the consumption of high cholesterol foods. In the third group compared to the control group, triglyceride, total cholesterol and LDL-C have significantly reduced and HDL-C was significantly increased, which indicates the negative effect of drug with a dose of 80 mg per kg at the end of the twelfth week (05 / 0P <). Itraconazole by reducing serum level of cholesterol will slow the process of Atherosclerosis.

KEYWORDS: Itraconazole; Atherosclerosis; Rabbits; Hyperlipidemic

[ HTML Full Text]