Analgesic and antiinflammatory study of surfactant modified liposomes

P. Muthuprasanna¹, K. Suriaprabha²*, T. srinivasa Rao¹, Vidya Mandava¹ and B. Sindhu¹

¹Department of pharmaceutics, Vels College of pharmacy, Chennai - 600 117 India.

²Department of Pharmaceutics, C.L. Baid Mehta College of Pharmacy, Thorappakkam, Chennai - 600 096 India.

Corresponding Author E-mail: suriaapril14@yahoo.com

ABSTRACT: Liposomes are microscopic structures consisting one or more concentric lipid bilayers surrounding aqueous compartment within which water soluble drugs can be entrapped.Tween80 plays a vital role by increasing the drug permeation into the stratum corneum. In the present study, modified liposomes were produced by incorporating surfactant - polysorbate80 (Tween 80) into the lipid bilayer. The liposomes exhibited a superior entrapment stability compared with that of surfactant free liposomes (i.e., liposomes prepared with lipids and cholesterol).The invivo studies were carried to determine the effect of various formulation such as negative control (NC) which is a plane corbopol gel, drug entrapped liposomes (L), marketed sample which is treated as positive control (PC) and surfactant modified liposomes (SL) in delivering the drug diclofenac sodium through the skin. The animals showed a very poor analgesic and anti inflammatory response when treated with negative control but showed an enhanced response when treated with positive control, liposomal gel and surfactant modified liposomal gel. Among these, the formulation –surfactant modified liposomal gel gave an improved response than the other two formulations.

KEYWORDS: Analgesic; antiinflammatory effect; liposomes

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