Comparison Of Probiotic Lactobacillusgr-1 And RC-14 With Metronidazole Oral Tablet For Treating Concurrent Bacterial And Trichomonialvaginitis: A Blind, Randomized,Clinical Trial

Mina Taheri¹, Khadijeh Abdali*¹, Sedigheh Amooee², Mehrab Sayadi³

¹Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. ²Division of Infertility and Gynecologic Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran ³Statistician, Shiraz University of Medical Sciences, Shiraz, Iran.

DOI : http://dx.doi.org/10.13005/bbra/2006

ABSTRACT: Comparison of the effects of oral Metronidazole and vaginal probiotic capsule in the women suffering from concurrent bacterial and trichomonial vaginitis A total of 76 women with concurrent bacterial and trichomonial vaginitis were randomly divided into 2 groups.Group A was treated with a twice daily dose of 500mg oral Metronidazole for 7 days.Group B was treated by vaginal probiotic capsule containing lactobacillus rhamnosus GR-1 and lactobacillus reuteri RC-14 once a day for 10 days.Clinical signs, gram stain, PH and wet smear were measured in both groups before and after the intervention. The data were analyzed using the SPSS statistical software (v. 16) and McNemar and Chi-square tests. No significant difference was observed between the two groups regarding the clinical signs on the 8^th and the 11^th days (P>0.05). Also, a significant difference was found between the two groups regarding the wet smear results (P<0.05). After the follow-up, a significantly higher number of women receiving the probiotic capsule had normal vaginal flora and desirable vaginal PH compared to the Metronidazole group (P<0.05). Application of vaginal probiotic capsule leads to the stability of the vaginal ecosystem and prevents the growth of the pathogenic bacteria as well as the other pathogens.

KEYWORDS: Oral Metronidazole; Vaginal probiotic capsule; Concurrent bacterial; trichomonial vaginitis

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