Activity of Indian Habitat Plants Extracts Against Mycobacterium Tuberculosis to Treat TuberculosisActivity of Indian Habitat Plants Extracts Against Mycobacterium Tuberculosis to Treat Tuberculosis

S. C. Narwadiya¹, S. V. Saoji², U. L. Dhumne³, P. M. Tumane¹ and V. G. Meshram⁴

¹P.G. Department of Microbiology, R.T.M Nagpur University Nagpur India.

²Su-Wishwas Diagnostic Centre,Central Bazar Road, Ramdaspeth Nagpur India.

³National Institute of Miners’ Health, JNARDDC Campus Opp wadi Police Station Wadi, Nagpur India.

⁴Sindhu Mahavidyalaya,Panchpaoli, Nagpur India.

ABSTRACT: Tuberculosis (TB) kills about 3 million people per year worldwide. Furthermore, TB is an infectious disease associated with HIV patients, and there is a rise in multidrug-resistant TB (MDR-TB) cases around the world. The study evaluated the anti mycobacterial activity of ethanolic extracts of four plants from Indian habitat for in vitro anti tubercle activity. Experiments were conducted to study the effect of extracts against drug-resistant M. tuberculosis isolates.Out of four plants Pheonix dactylifera showed the best activity (MIC = 100 μg/mL) against the sensitive Mycobacterium tuberculosis strains. The following plants were active also but at 200 μg/mL or above level Abutilon indicum, Swertia chireta, Allium cepa. The testing was performed on H37Rv strain of Mycobacterium tuberculosis and was found to be being inhibited by the alcoholic extracts of Pheonix dactylifera and Abutilon indicum. These data point to the importance of biological testing of extracts against drug-resistant M. tuberculosis isolates.

KEYWORDS: Mycobacterium tuberculosis; Herbal Medicine; Treatment of TB

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