The Antioxidant Effect of Ethanolic Bark Extract of Ougeinia Oojeinensis (Roxb.) Hochr on Ccl4 Induced Liver Damage

R.k. Sahu¹*, U. Sharma², A. Roy¹, D. Dewangan² and K.P. Namdeo³

¹Department of Pharmacognosy, Oriental College of Pharmacy, Bhopal India.

²Aristo Pharmaceutical Pvt. Ltd., Mandideep, Raisen India.

³Smt. S.L.T. Institute of Pharmaceutical Sciences, Bilaspur India.

Corresponding Author E-mail: ramsahu79@yahoo.co.in

ABSTRACT: In this paper, the antioxidant activity of ethanolic bark extract of Ougeinia oojeinensis (Roxb.) Hochr. on the CCl4-induced liver damage in rats, is reported. In hepatotoxic rats, liver damage was studied by assessing parameters such as lipid peroxidation levels, catalase activity, glutathione peroxidase activity and superoxide dismutase activities were employed as biomarkers of liver damage, under control condition and after the administration of 100 mg/kg and 200 mg/kg, respectively. Our result suggests that the ethanolic bark extract of O. oojeinensis showed a significant antioxidant activity. Superoxide dismutase, catalase and glutathione peroxidase activities were increased, whereas lipid peroxidation is significantly decreased in the ethanolic bark extract-treated group, in comparison to the CCl4 group. Hence, the ethanolic bark extract, at the aforementioned doses, showed significant protection under CCl4-induced hepatocellular injury.

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