Clinical Assessment of Isoniazid (INH) Acetylator Phenotype of Mycobacterium Tuberclulosis Infected Patients in Alushi-Akwanga

J. P. Mairiga* and P. G. C. Odeigahh  

Department of Cell Biology and Genetics, University of Lagos, Akoka Nigeria.  

ABSTRACT: A cinical study of Isoniazid (INH) acetylator phenotype was carried out in 79 in-patients under going pulmonary Mycobacterium tuberculosis treatment in Alushi Medical Center in Nasarawa State. Isoniazid acetylator in the tuberculosis patients was determined using dosage and urinalysis technique. The distribution was bimodal with an antimode at 70-74%. On this basis, Forty (40) or 50.63% of the sampled population of the patients were rapid acetylators, thirty six (36) or 45.57% were slow acetylators, while three (3) or 3.80% were unclassified. The calculation of gene frequencies using Hard Weinberg theorem showed a dominant allelic (R) Frequencies of 0.2974 and 0.7026 for recessive allele. Inferences drawn suggest that a high proportion of the rapid acetylators from the sampled population may be heterozygous.

KEYWORDS: Acetylator; phenotype; tuberculosis; isoniazid; urinalysis

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