Volume 6, number 1
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5-(1H-Indol-3-Ylmethyl)-N-(Substituted Phenyl)-1, 2, 4-Thiadiazol-2-Amine Derivatives: Synthesis and Biological Screening

Nadeem Siddiqui and M. Shamsher Alam

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University) New Delhi - 110 062 (India)

ABSTRACT: A number of new 5-(1H-indol-3-ylmethyl)-N-(substituted phenyl)-1, 2, 4-thiadiazol-2-amine derivatives (1-10) were synthesized and evaluated for their antibacterial and antifungal activity. The titled compounds (1-10) were obtained by cyclization of 2-(1H-indol-3-yl acetyl)-N-(substituted pheynyl) hydrazine carbothioamide in presence of conc. Sulphuric acid. The structures of newly synthesized compounds were characterized by spectral and elemental analyses. Compounds (1 and 4) showed 80% and 72% inhibition respectively against S. aureus while as compounds (2, 3 and 4) showed 76% inhibition against E.coli. Compounds (1, 4 and 8) showed 70%, 85% and 65% inhibition respectively against C. albicans.

KEYWORDS: 1, 3, 4-thiadiazole derivatives;antimicrobial activity

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Siddiqui N, Alam M, S. 5-(1H-Indol-3-Ylmethyl)-N-(Substituted Phenyl)-1, 2, 4-Thiadiazol-2-Amine Derivatives: Synthesis and Biological Screening. Biosci Biotechnol Res Asia 2009;6(1)
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Siddiqui N, Alam M, S. 5-(1H-Indol-3-Ylmethyl)-N-(Substituted Phenyl)-1, 2, 4-Thiadiazol-2-Amine Derivatives: Synthesis and Biological Screening. Biosci Biotechnol Res Asia 2009;6(1). Available from: https://www.biotech-asia.org/?p=8152

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