Formulation of Mouth Dissolving Tablets of Glipizide by Microencapsulation Technique Using Various Polymers

Arun Kumar¹*, Pankaj Kumar Sharma² and Pradeep kumar³    

¹NKBR Colege of Pharmacy and Research Center, Meerut India.

²Raj Kumar Goel Institute of Technology, Ghaziabad India.

³pes College of Pharmacy, Bangalore India.

ABSTRACT: Mouth dissolving tablet of glipizide was prepared by using the micro encapsules of Ethylcellulose. The micro encapsules was prepared by Coacervation-phase separation method by using different polymers like Xanthan gum, HPMC and Ethylcellulose. The best result was fond of Ethylcellulose. Mouths feel taste was excellent after studied on 10 volunteers and no bitter taste or grittiness claimed by volunteers. The % drug release was 95.95% in 24 hrs which is much better then other formulations. The study was of Fast release component for quick onset of action by absorption through oral mucosa. Controlled release component, which will form a suspension in the oral cavity and after swallowing of the suspension, will provide sustained action of the drug. Purpose to included controlled component in mouth dissolving tablet is that to reduce dosing frequency, Increase t½ and controlled blood glucose level for prolonged period of time. This has been achieved after disintegration and dissolution studied the mouth dissolving tablets of glipizide by using the micro encapsulation technique. Problems of swallowing encountered by pediatric and geriatric patients can be overcome by formulating mouth-dissolving tablets.

KEYWORDS: Glipizide; fast release; mouth dissolving tablets; micro encapsulation; xanthan gum

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