Study the Adverse Effects of Antibiotic Maxipime (Cefepime Hydrochloride) on the Evolution of Composition of the Liver in Albino Rats During Pregnancy and Lactation

Samira Omar Abu Bakr Balubaid

Department of Biology, Faculty of Science, King Abdul Aziz University, Jeddah Saudi Arabia.

ABSTRACT: The aim of this study was to identify the impact of the new antibiotic “Maxipime” (Cefepime hydrochlorid) “, which belongs to cephalosporin group on the development of composition of the liver in fetuses, infants’ white rats during pregnancy and lactation. Using Maxipime drug during the different phases of pregnancy, invagination (0-7 day) ,organs formation (7-14 day) and growth period (14-21 day) led to a lot of pathological changes in the fetal liver and these changes were obviously appeared in the first and second trimester. The histological examination of rat liver during lactation showed a decrease in the impact of the drug at the age of one week of lactation, and this effect restricted on limited areas at 14 days age and the liver with normal hepatic structure at the end of weaning age .It was evident in the low intensity of these effects during the lactation period in the histological sections of the maternal liver as restricted to limited areas, while included most of the liver tissue during pregnancy. Therefore, it is recommended to: never provide Maxipime during gestation especially during the first and second period and treatment with Maxipime should not be used during lactation before the 14th day of delivery.

KEYWORDS: pregnancy and lactation liver; albino rats; Maxipime;

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