Effect Of Neem Seed Oil on Body and Organ Weights of Male Wistar Rats

A. O. Nwaiho¹, L. E. Ebite²*, K. E. Nwangwa¹ and Ovuakporaye Saimon¹*

¹Department of Physiology, Delta State University, Abraka, Nigeria.

²Department of Anatomy, Delta State University, Abraka, Nigeria.

ABSTRACT: The effect of Neen seed oil on body and organ weights of male Wister rats were investigated were invested. Twenty-one male Wistar rats were investigatedweighing on the averate 150g were randomly divided into three groups (n=7) – A, B and C. Group A served as control and received on oral dose of 0.5ml of Normal saline daily for 6 weeks. Group B and C served as esperimental groups. B received 0.5ml of neem seed oil for 6 weeks while group C received 0.5ml of neem seed oil for 4 weeks only, and allowed 2 weeks of non administration. The animals were weighed and sacrificed and the liver, spleen, kidney, testis and brain were removed after laprotomy and were cleanedand weighed. Data analysis was done using the students t-test Result showed. Result showed statistically significant reduction (P<0.05) in body, testis, liver, kidney and brain weight in experimental animals compared to control. Despite the benefit afforded by neem seed oil in several trails for male contraception, this work suggested that it may have adverse effect on important organs of the body.

KEYWORDS: Neem seed oil; male wistar rats

[ HTML Full Text]