Volume 6, number 2
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Formulation and Evaluation of Quetiapine Fumarate Sustained Release Tablets

V. RavichandIran

Department of Pharmaceutics, Vels college of Pharmacy India.

Corresponding Author E-mail: sen03mpharm@gmail.com

ABSTRACT: Sustained release tablets of Quetiapine fumarate were prepared by wet granulation method using different polymers polymers HPMC K 4M , HPMC K 100M & EC in different ratios(F1 to F7)Dissolution was carried out in 0.1N Hcl & pH6.2 buffer. Dissolution tests are performed for successive batches and polymers were changed in each formulation. For seventh formulation maximum %Drug release was observed, in which ratio of two polymers HPMC K 4M & ETHYL CELLULOSE is 1:2. The % Drug release was very poor for polymers HPMC K 100M when compared to polymers HPMC K 4M & ETHYL CELLULOSE is 1:2.The dissolution profile of final batch(HPMC K 4M & ETHYL CELLULOSE 1:2.)compared with reference product which were found to be comparable with the reference product

KEYWORDS: Quetiapine fumarate; HPMC K 4M; ethyl cellulose; Sustained release tablets

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RavichandIran. V. Formulation and Evaluation of Quetiapine Fumarate Sustained Release Tablets. Biosci Biotechnol Res Asia 2009;6(2)
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RavichandIran. V. Formulation and Evaluation of Quetiapine Fumarate Sustained Release Tablets. Biosci Biotechnol Res Asia 2009;6(2). Available from: https://www.biotech-asia.org/?p=8768.

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