Influence of Terminalia Belerica Fruits Extracts on Glycoprotein Components in Streptozotocin Induced Diabetic Rats

G. Saravanan, M. Fredi Moses, S. Karthickeyan and G. P. Senthilkumar*

Department of Biotechnology, Centre for Biological Sciences, K.S.R. College of Arts and Science, Tiruchengode - 637 215 India.

ABSTRACT: The present study investigated the effect of aqueous bark extracts of Terminalia belerica (T. belerica) on dearrangement in glycoprotein levels in the streptozotocin-induced diabetic rats. The extract of T. belerica (150 mg/kg b.w/day) was administered orally for 30 days to normal and diabetic rats. The effects of extract on glucose and plasma glycoproteins were studied. The effect of fruit extract was compared with gliclazide, a reference drug. The levels of glucose, glycosylated haemoglobin and plasma glycoproteins containing hexose, hexosamine, fucose and sialic acid were increased significantly in diabetic rats. Administration of T. belerica (150 mg/kg) to diabetic rats significantly restored the level of glucose, glyosylated haemoglobin and plasma glycoproteins near normal. The present study indicates that the fruit extract of T. belerica possesses a significantly beneficial effect on the glycoprotein moiety in addition to its anti-diabetic effect.

KEYWORDS: Terminalia belerica; Streptozotocin; glycoprotein components; Diabetes

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