In-Vivo Antioxidant Activity of Premna Serratifolia Linn. in High Fat Diet Fed Rabbits

Rekha Rajendran*, M. Srinivasan, Sohel Bavan and R. Sundharajan

Department of Pharmacognosy, Mohamed Sathak A.J. College of Pharmacy, Sholinganallur, Chennai - 600 119 India.

Corresponding Author E-mail: rekhacognosy@rediffmail.com

ABSTRACT: Antioxidant activity of the ethanol extract of stem-bark & stem-wood of Premna serratifolia Linn., (Verbenaceae) was determined by high fat diet (HFD) induced oxidative stress in rabbits. Preliminary phytochemical analysis of the ethanol extract revealed the presence of phytoconstituents such as alkaloids, flavonoids & phenolic compounds. The ethanol extract of stem-bark & stem-wood of P. serratifolia Linn., showed significant antioxidant activity by lowering the enzyme levels of (TBARS) thiobarbituric acid reactive substance & by increasing the enzyme levels of catalase (CAT), glutathione (GSH) & super oxide dismutase (SOD), which is comparable with the standard Atorvastatin in a dose dependent manner & remarkable activities to scavenge reactive oxygen speices (ROS) may be attributed to the high amount of hydrophilic phenolic compounds. It is confirmed that the ethanol extract of P. serattifolia Linn., possesses the antioxidant substance, which may be potentially responsible for the cardio protective activity & chemo protective mechanism as well as using this plants extract in folkloric remedies.

KEYWORDS: Premna serratifolia; ethanol extract; atorvastatin; antioxidant activity

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