Protective Effect of Marjoram Plant against the Toxicity of Cadmium Chloride in Testes of Albino Rat

Samira Omar Abu Bakr Balubaid

Department of Biology, Faculty of Science, King Abdul Aziz University, Jeddah Saudi Arabia.

ABSTRACT:

Due to the extensive use of the marjoram plant in the treatment of some diseases, with a lack of its scientific research , there for the aim of this study was to identify the extent of safety when used and to study its protective effect against the toxicity of cadmium chloride on testicular tissue. Thirty male albino rats ( 60- days) age divided into four groups, the first group ( control group ) , group II treated with cadmium chloride (2mg/kg), the third group treated with marjoram (2mg/kg), the fourth group treated with both cadmium(2mg/kg) and marjoram(2mg/kg). Cadmium treated group showed imbalance in both structure and physiology of the testis .Also, an obstruction of spermatogenesis and spermiogenesis process appeared as degradation of spermatocytes, decrease in their number and distort their structure with low testosterone level . The third group treated with marjoram only showed similarity to the control structure with increased density of spermatocytes and sperm, also the testosterone level was comparable to the control group. Co- administration of cadmium and marjoram lessened most histopathological changes in tissue structure and balance the testosterone level . Thus it was recommend : Non-use of cadmium metal and try to find a replacement for it in industry because of its adverse effect on male fertility .Also ,we hope of using marjoram as protective agent for its safe on tissue and increases the rate of male fertility

KEYWORDS: cadmium chloride; albino rat-testis; marjoram; testosterone

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