Possible Ameliorative Role of Some Compounds on the Side Effects of Avandia (Drug)

Abd El-Aziz A. Diab¹, Mansour H. Zahra¹, Ahmed A. Hendawy¹, Samih¹, I. El-Dahmy²* And Reham Z. Hamza¹

¹Department of Zoology, Faculty of Science, Zagazig University, Cairo Egypt.

²*Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Zagazig University, Cairo Egypt.

ABSTRACT:

The present study was carried out to evaluate the hypoglycemic effect of Avandia, Nigella sativa, Silymarin each alone and the combination of Avandia with either Nigella sativa or Silymarin In order to get the best combination to avoid the possible side effects produced by Avandia. This was done through studying the effect of the test plant drugs and their combination on serum glucose, insulin , some liver and kidney function parameters .seven groups of adult male rats each of 10 (200-250 gm / b.wt) were used in this study . Hyperglycemia was induced in six groups of rats. Whereas, the seventh group was left as normal control group. All treatments were given orally daily for successive 28 days .The first group was left without treatment and kept as STZ diabetic. The 2nd group was administered Avandia (0.58mg/100gm.b.wt) , The third group was given Nigella sativa(0.25gm/100gm.b.wt) , the 4th group was given Silymarin (50mg/100gm.b.wt), The 6thand 7th groups were administered the combination of Avandia with either Nigella sativa or Silymarin respectively in the same recommended doses. Blood samples were collected after 1st, 2nd, 3rd and 4th week post drug administration. Serum was separated and used for determination of various variables. The results showed that Avandia afforded a marked increase in serum ALT, AST, LDH activities, Serum urea, Uric acid and creatinine as well a significant elevation in blood glucose level and significant decrease in serum insulin level. Treatment of diabetic rats with various treatments elicited a marked decrease in serum ALT,AST,LDH, Urea, Uric acid and creatinine as well as a marked decrease and increase in blood glucose and serum insulin respectively when compared with diabetic non treated group .The best results was obtained with the combination of Avandia+ Silymarin on blood sugar and insulin levels.

KEYWORDS: Nigella sativa; Avandia and Anti diabetic drug.

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