Volume 7, number 2
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Large Scale Production of Oxytetracyclin Using Streptomyces Varsovances

Abhishek Mule*, R.C. Patil1*, Ujwala Jadhav2, V.I. Katchi3, Asha J. Rao3 and S.K. Gaikwad4

1Department of Microbiology, Bhavan’s College, Andheri (W), Mumbai - 400 058 (India). 2Department of Life Science, University of Mumbai, Santa Cruz (E), Mumbai - 400 098 (India). 3Department of Zoology, Bhavan’s College, Andheri (W), Mumbai - 400 058 (India). 4Department Of Cell and Molecular Biology, Rajiv Gandhi Institute of IT and Biotechnology Bharati Vidyapeeth University (India).

ABSTRACT: Oxytetracyclin production by Streptomyces varsovances was done using sweet potato mash medium. Important process parameters like optimum pH ,temperature, tip speed and Kla value for the antibiotic production was determined. Extraction of oxytetracyclin was carried out using boron tetrafluoride, extracted antibiotic was estimated using bioassay and HPLC. New production method was effective and gave 25% more yield as compared to traditional methods, extraction method is promising for large scale production.

KEYWORDS: Oxytetracyclin; pH; temperature; tip speed; boron tetrafluoride

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Mule A, Patil R. C, Jadhav U, Katchi V. I, Rao A. J, Gaikwad S. K, Mammen A. Large Scale Production of Oxytetracyclin Using Streptomyces Varsovances. Biosci Biotech Res Asia 2010;7(2)
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Mule A, Patil R. C, Jadhav U, Katchi V. I, Rao A. J, Gaikwad S. K, Mammen A. Large Scale Production of Oxytetracyclin Using Streptomyces Varsovances. Biosci Biotech Res Asia 2010;7(2). Available from:https://www.biotech-asia.org/?p=9294

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