Histopathological and Ultrastructural Study on the Effect of Green Tea Extracts on Ovarian Cancer Model

F. A. Mahboub, A. M. Ali and F. A. Khorshid*

Department of Medical Biology, KAAU Head of Tissue Culture Unit , KFMRC, Saudi Arabia.

ABSTRACT: Green tea has shown promise in the prevention of several cancers due to its chemoprevention properties. This study investigated the role of green tea extracts against ovarian cancer metastasis of leukemic cells in female mouse model. Animals were divided to: control group, infected by leukemic cells and experimental group, which was infected then treated with green tea extracts on day (0) of infection. Animals were scarified after 2-10 weeks following injection; the ovaries were quickly removed then preceded for histological examinations by light and electron microscopy. Light microscopy results were well illustrated with their cyto-structure by using transmission electron microscopy. Histopathological examination of infected non-treated group revealed that, completely no follicles were shown, the entire ovary crowded with cancerous cells and L1210 cells attacked the ovarian parenchyma whereas, in treated group, significant improvement in histological and ultrastructural examination were observed in ovarian parenchyma and all follicles types reappeared again.

KEYWORDS: Green Tea Extracts; L1210 cells; Ovarian cancer; Histopathological; Ultrastructural

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