Preparation and Physicochemical Characterization of Solid Dispersion of Aceclofenac Formulated by Solvent Evaporation Method

Ayyappan Thiyagarajan¹*, Vetrichelvan Thangarasu¹ and Darlinquine Sabarimuthu²

¹Department of Pharmaceutics, Adhiparasakthi College of Pharmacy, Melmaruvathur - 603 319 India.

²SASTRA University, Thanjavur - 613 401 India.

ABSTRACT: Aceclofenac, a widely prescribed non- steroidal anti inflammatory drug is practically insoluble in water and aqueous fluids, because it exhibits poor and variable dissolution rate and oral bioavailability. The objective of the study is to investigate feasibility of enhancing the dissolution rate of aceclofenac. Solid dispersions prepared by solvent evaporation method with crosspovidine as a new class of dissolution enhancing carrier. The prepared solid dispersions characterized in terms of UV-Visible spectroscopy, IR spectra, thermal behaviour (differential scanning calorimetry, DSC), X-ray diffraction (XRD), morphology (scanning electron microscopy, SEM).The DSC showed a decrease in the melting enthalpy indicating disorder in the crystalline content. The DSC showed, decreased drug crystallinity, altered surface morphology and micronization.The XRD also revealed a characteristic decrease in crystallinity. The drug content in all the formulation was found to be within the official limit. The dissolution rate of aceclofenac solid dispersion could be enhanced markedly higher than pure drug.

KEYWORDS: Aceclofenac; Dissolution rate; Solid dispersion Crosspovidone

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