Evaluation of Antimicrobial Agent from Leaves of Synadenium Grantii Hk.F.Bot.Mag

Madhavi Adhav, Bhavesh Patel and Anil Gharia

Department of Botany, Department of Microbiology, Department of Chemistry P.M.B. Gujarati Science College, Indore India.    

ABSTRACT: Higher plants have played a dominant role in the introduction of new therapeutic agents. In India, there are over 15000 kinds of naturally occuring higher plants1. About 2000 species of these are reported to posses medicinal values. Discovery and development of new therapeutic agents is a continuing process. In spite of the fact that at present we have our command a formidable array of modern drugs, the need to discover and invent new agents is geniune and urgent. Many of the members of family Euphorbiaceae are known because of their medicinal uses in tribals as well as in Ayurveda2,3,4. Present paper deals with one of such medicinally important plant Synadenium grantii. Antimicrobial studies of leaves extract of S. grantii shows strong antibacterial activity against gram positive bacteria viz. S. aureus and Streptococcus sp. and gram negative bacteria viz. E. coli, S. dysentrae, S. typhi, P. aeruginosa and K. pneumoniae. The IR of active fraction shows the presence of secondary amine, amide groups, Co-NH2-C-N ring vibration. This proves its correlation with antimicrobial study.

KEYWORDS: Synadenium grantii; antimicrobial activity; therapeutic agents

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