Effect of Antitubercular Therapy on Serum Levels of Tumor Necrosis Factor Alpha and Malondialdehyde

Rashmi Kulkarni¹*, Kiran Saxena², Meena Verma³, Akhouri Sinha⁴, Ajit Deshpande⁵ and Vandana Verma⁶

¹Department of Biochemistry, 604, Adarsh Appartment, Sri Aurobindo Institute of Medical Sciences, Indore India.

2Department of Biochemistry, College of Medical Sciences, Amargadh.

3Department of Biochemistry, MGM Medical College, Indore India.

4Department of Biochemistry, Chirayu Medical College Hospital, Bhopal India.

5Department of Community Medicine, Shri Aurobindo Institute of Medical Sciences, Indore India.

6Department of Biochemistry MGM Medical College, Indore India.

Corresponding Author E-mail:– rashmiak1121@rediffmail.com

ABSTRACT: To find out effect of antitubercular therapy on serum levels of Tumor necrosis factor alpha (TNF a) & Malondialdehyde (MDA). The present study was conducted in Department of Biochemistry and patients were selected from Department of TB and Chest Shri Aurobindo Institute of Medical sciences and amp; Manorama Raje Tuberculosis hospital, Indore. 32 healthy controls and 35 Pulmonary TB Patients were compared initially for serum MDA and TNF a levels. The serum TNF ? and MDA levels of PTB patients were again estimated after one month of antitubercular therapy. TNF ? & MDA levels in serum were significantly increased (p<0.001) in pulmonary tuberculosis patients when compared with control. Antitubercular therapy significantly decreases TNF a & MDA levels (p<0.05). The study indicates that TNF a and MDA are the important parameters in evaluating the severity of disease and monitoring of the clinical effect of the antituberculosis drugs (DOTS) over a period of prescribed drug therapy.

KEYWORDS: Tuberculosis; TNF alpha; malondialdehyde; antitubercular treatment

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