Effect of Dose Dependent Administration of Zidovudine on the Weight of Wistar Rats (Rattus novergicus)

Lilian Ebele Chris-ozoko (Nee Ebite)

Department of Anatomy, Delta State University Abraka, Nigeria.

ABSTRACT: Zidovudine is a type of medicine called a nucleoside reverse transcriptase inhibitor (NRTI). It works by disrupting one of the early steps in the HIV life cycle, called reverse transcription. Twenty (20) adult wistar male rats, with an average weight of 150grams were used for this study. They were divided into four (4) groups made up of five (5) rats each,. Daily consumption of 0.3mg/ml,1.3mg/ml,and 2.3mg/ml of zidovudine, in consonance with the administration by Sikka et al (1991), was administered orally to rats in groups two (2) (subnormal dose group), three (3) (normal dose group), and four (4) (excess dose group) respectively for thirty days using an Orogastric cannula, while rats in group one were administered distilled water only. The rats were also weighed weekly, for four weeks.

KEYWORDS: Zodpvidome; Wistar Rats

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