Hepatoprotective and Curative Effect of Eclipta prostrata on CCl4 Induced Hepatotoxicity in Albino Rats

B. Dheeba¹, E. Vaishnavi¹, P. Sampathkumar¹ and M. Kannan²

¹Department of Biosciences, SRC, SASTRA University, Kumbakonam - 626 001, India.

²Department of Microbiology, V.H.N.S.N. College, Virudhunagar - 626 001, India .

Corresponding Author E-mail:deepabaskaran76@gmail.com

ABSTRACT: The combined antioxidant and hepatoprotective effect of Eclipta prostrata was evaluated against carbon tetra chloride (CCl4) induced hepatic damage in wistar albino rats. Ethanolic extract from the Eclipta prostrata at a dose level of 200mg/kg of body weight was administered orally daily once for 15 days. The substantially elevated serum marker enzymes such as Aspartate transaminase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP), Acid phosphatase (ACP) and the antioxidant enzymes such as glutathione peroxidase, superoxide dismutase and catalase were found due to CCl4 treatment. The levels of above mentioned enzymes were brought to near normalcy after administration of plant extract. The biochemical parameters like total protein, total bilirubin were also restored towards normal levels. In addition Eclipta prostrata significantly decrease the liver weight of CCl4 intoxicated rats. Silymarin at a dose level of 25mg/kg was used as a standard reference drug for comparison.. The results of this study strongly indicate that Eclipta prostrata is having a potent hepatoprotective action against CCl4 induced hepatic damage in rats.

KEYWORDS: Hepatoprotective; Marker Enzymes; Eclipta prostrata; Carbon Tetra Chloride

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