Manuscript accepted on :
Published online on: 28-06-2013
The Effect of Etoposide Drug on Chromosomal Changes and Mitotic Index in Mouse Bone Marrow Cells
Abdul Rahman A. I. Alyahya
College of Science, Shaqra University, Saudi Arabia.
DOI : http://dx.doi.org/10.13005/bbra/1105
ABSTRACT: Etoposide is one of the important chemical drugs commonly used worldwide in the treatment of many cancers and it is classified as an anti metabolic drug as it disrupt the process of multiplication of DNA in cancer cells by inhibiting DNA topoisomerase II causing the death of cancer cells. We select short-term tests in the current study, because it is a quick and accurate indicator to study the effect of chemicals and drugs on biological systems. As there are changes can determined accurately by cytological examination. Laboratory male mice of pure SWR / J were exposed to three types of concentrations (20, 40, 60 mg / kg) of Etoposide at different times to study its effect on the index rate of indirect cell division, and the extent of chromosomal abnormalities that can be caused. Treatment with Etoposide drug led to significant decrease in the index rate of cell division and significant increase of chromosomal abnormalities, and it correlates directly with concentration and inversely with the passage of time after treatment.
KEYWORDS: Etoposide; Mitotic index; Chromosomal abnormalities
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| Copy the following to cite this article: Alyahya A. R. A. I. The Effect of Etoposide Drug on Chromosomal Changes and Mitotic Index in Mouse Bone Marrow Cells. Biosci Biotechnol Res Asia 2013;10(1) |
| Copy the following to cite this URL: Alyahya A. R. A. I. The Effect of Etoposide Drug on Chromosomal Changes and Mitotic Index in Mouse Bone Marrow Cells. Biosci Biotechnol Res Asia 2013;10(1). Available from:https://www.biotech-asia.org/?p=10260 |
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