An Antibacterial, Antifungal and Anthelmintic Evaluations of Some Synthesized Chalcone Derived Benzimidazoles

I. Sudheer Babu and S. Selvakumar*

Department of Pharmaceutical Chemistry, Sir.C.R.Reddy College of Pharmaceutical Sciences, West Godavari (Dist), Eluru - 534 007, India.

ABSTRACT: The Chalcone nucleus based natural plant products have various biological activities due to their highly reactive a, b unsaturated carbonyl group. If these medicinal plants not traceable in nature we must go through new synthetic drugs as a source of chalcone analogues. So we synthesized a series of chalcone derived benzimidazoles by condensation of 2-acetyl benzimidazole in alkali with various aromatic aldehydes. The synthesized chalcones were screened for their in-vitro antimicrobial activity using disc diffusion and broth micro-dilution assays. The synthesized chalcones shows good activity against the tested fungal species. They have better activity against gram positive bacteria but shows poor activity against gram negative bacteria. The In-vitro anthelmintic screening of all chalcones exhibited significant potency when compared to standard drug albendazole.

KEYWORDS: Chalcones; Benzimidazolyl chalcones; Antibacterial; Antifungal; anthelmintic

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