Molecular Docking Analysis of Compounds Lavandula angustifolia Mill with Gabaa Receptor Lessen Stress

Ali Kazemi Babaheydari1*, Ehsan Heidari Soureshjani^2-3 and Roya Salehi³

1Department of Chemistry, Faculty of Science, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran. 2Department of Biological, Faculty of Science, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran. 3Young Researchers Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

DOI : http://dx.doi.org/10.13005/bbra/1188

ABSTRACT:

GABAA receptors are hetero-oligomeric Cl- channels that are elective blocked by the alkaloid bicuculline and modulated by steroids, barbiturates and benzodiazepines. The anticonvulsant activity of diazepam and phenobarbital may be mediated in Section by enhancement of inhibition involving y-aminobutyric acid (GABA). Lavender is one of the maximum effective medicinal plants various therapeutic effects of lavender, so as sedative, spasmolytic, antiviral, and antibacterial activities have been reportage. The molecular docking analysis done indicates that the receptor of GABA interaction with the Lavandula angustifolia Mill compounds effectively. Ligand Lavandula angustifolia Mill compounds with GABAA are safer and milder with fewer or no side effects than the drugs currently used in the remedy of lessening high Stress which can be better for the development of new therapeutics to blocked GABAA lessening stress. Results conûrm all the Lavandula angustifolia Mill compounds were good binding energy when compared with the binging energies of diazepam (-295.80) Among all the Lavandula angustifolia Mill compounds, the indicate nigh binding energy value (-256.12).

KEYWORDS: Hex (6.1); Lavandula angustifolia Mill; Docking; GABAA receptors

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