Altered Resting-state Functional Connectivity Patterns of Several Frontal and DMN Related Areas in Children with Attention Deficit Hyperactivity Disorder

B. Shekarchi¹, M. Hosein Lashkari²*, A. Mehrvar³, A. Akbarian Aghdam⁴ and S. Fartook Zadeh⁵

¹Department of Radiology, AJA University of Medical Science, Tehran, Iran. ²Department of Surgery, AJA University of Medical Science, Tehran, Iran. ³Department of Pediatric, AJA University of Medical Science, Tehran, Iran. ⁴Department of Electrical Engineering, Sharif University of Tehran, Iran. ⁵Department of Cardiology, AJA University of Medical Science,Tehran, Iran.

ABSTRACT: Attention Deficit Hyperactivity Disorder (ADHD) affects nearly 5% of school-aged children and generally it continues to adulthood. Neural basis of ADHD has been a matter of debate in recent decades. In this study a group independent component analysis based study has been done on 21 ADHD individuals and 21 control group. Spatial maps have been derived using dual regression method. Several differences have been found in frontal pole (specifically anterior cingulate cortex and inferior frontal gyrus). Posterior components of DMN, cerebellum and brainstem (pons) in the form of decreased activation compared to control group.

KEYWORDS: Children with attention deficit; DMN; Patterns of several frontal

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