Effects of Raloxifeneon on Ovarian Tisue of Mature Female Rats

Ebadi Zahra¹, Kargar Jahromi Hossein¹, Abedi Hassan Ali²*, Farzam Mohsen³ and Farzam Mohammad⁴

¹Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran. ²Research Center for Noncommunicable Diseases, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran. ³Department of Physiology, Veterinary School, Kazerun Branch, Islamic Azad University, Kazerun, Iran. ⁴Department of Anatomy and Embryology, International Branch, Shiraz University, Shiraz, Iran.

ABSTRACT: Raloxifene as a selective non-steroidal regulator has profound estrogen-like effects on bone but anti-estrogen effects on endometrium and breast tissue. The aim of this study is to evaluate the effect of Intra-peritoneal injection of Raloxifene in different doses on ovarian tissue of mature female rats. Forty female Wistar rats weighing 180 20 g range were selected and divided into control, sham and experimental (1,2,3) groups. Raloxifene dissolved in distilled water with dosage of 30, 60 and 120 mg/kg BW were within four weeks injected to experimental groups1, 2 and 3 respectively. Control group did not receive any drugs while sham group received distilled water. All the injections were conducted intraperitoneally in patological studies. The parameters were the counts of initial, first, secondary, graph, uterus follicles and yellow body. The results of initial and uterus follicles counts in comparison with the control group show no significant difference (P<0.05). Secondary and graph follicles in experimental groups 2 and 3 showed no significant decrease compared to the control group (P<0.05) and number of initial follicles and yellow body in experimental group 3 showed a significant decrease compared to the control group (P<0.05). Results revealed that Raloxifene may cause a slight change in the number of ovarian follicles.

KEYWORDS: Raloxifene; ovary; female rats

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