Protective Activity of Aqueous Pericarp Extract of Punica granatum Against Hyperglycaemia Induced by streptozotocin in Rats

Swathi Putta and Eswar Kumar Kilari

Pharmacology Division, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India.

DOI : http://dx.doi.org/ http://dx.doi.org/10.13005/bbra/1536

ABSTRACT:

Diabetes mellitus is a chronic metabolic disorder characterized by raise in blood glucose levels known as hyperglycemia. In the present study, the aqueous pericarp extract of Punica granatum (APPG) was evaluated for hypoglycemia and its antihyperglycemic activity in streptozotocin-induced diabetic rats. The % inhibition of blood glucose levels in hypoglycemic activity of APPG 50 mg/kg and 100 mg/kg were found to be 26.91% (3hr) & 34.67% (6h) and 22.51% (3hr) & 25.24%(6 hr) hypoglycaemic normal rats. The antihyperglycemic activity of APPG with 150 mg/kg and 300 mg/kg in STZ induced diabetic rats were found to be 31.38% and 35.42% at 6hr respectively. The biphasic reduction was observed in both in normal and diabetic rats might be due to biphasic absorption or biliary secretion of the active principle present in APPG. At the end of 12 weeks study period the serum parameters were found to be increased in diabetic rats and treatment with APPG there is a significant reduction in all the parameters. In conclusion, the APPG found to have significant antihyperglycemic, antihyperlipedemia activity and significant protection against the damage to kidney. Which might be due to antioxidant potentials like flavonoids, polyphenols and tannins present in the APPG.

KEYWORDS: Diabetes mellitus; antihyperglycemic activity; Punica granatum

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