Changes in Blood Biochemical Parameters in Rats Against the Background of Acute Combined Intoxication with Phenylhydrazine and Cobalt Nitrate and Drug Correction by “EPAM4

Zhanat Kadyrbekovna Zhaznayeva¹, Raikhan Rimbayevna Beisenova¹, Marat Rashitovich Khanturin¹, Gulnur Yerzhanovna Saspugayeva² and Danagul Rimbayevna Beisenova²

¹L.N. Gumilyov Eurasian National University Republic of Kazakhstan, 010008, Astana, 2 Satpayevast. ²S.Seifullin Kazakh Agrotechnical University Republic of Kazakhstan, 010000, 62Pobedyave Karaganda State University of the name of academician E.A. Buketov, Republic of Kazakhstan,100008, Karaganda, st.University 28

DOI : http://dx.doi.org/10.13005/bbra/2254

ABSTRACT: The article presents the results of studies of the effect of acute combined intoxication with phenylhydrazine and cobalt nitrate in the blood chemistry of the experimental rats, as well as correction of the drug “EPAM4.” It is found that high doses of studied toxicant cause mitochondrial damage of the heart muscle, cause hypoglycemia, disruption of protein metabolism in the muscles, changes in the liver parenchyma. It is shown that during the correction by the drug “EPAM 4” there was a restoration of AST activity, creatinine level in the muscle of the experimental animals, restoration of disturbed formations of total bilirubin in the cells of thymol test, glucose production.

KEYWORDS: phenylhydrazine; heavy metals; cobalt; glucose; thymol test; creatinine; ALT - alanine aminotransferase; AST - aspartate aminotransferase; hypoglycemia

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