The Effect of Injected Homatropine on Mortality and Signs of Organophosphate Poisoning in Lab Rats

Mahammadmehdi Heyran¹, Masoud Mayel¹, Mohsen Karvar², Maryam Mohammadi³ and Rezamirzaeeseyf Abad^4*

¹Assistant Professor and Emergency Medicine Specialist, Kerman University of Medical Science, Kerman, Iran.

²Surgeon of Kidney and Urinary Tract, Jiroft University of Medical Science, Jiroft, Iran.

³Resident of Emergency Medicine, Kerman University of Medical Science, Kerman, Iran.

⁴Phd of Nursing, Jiroft University of Medical Science, Jiroft, Iran.

DOI : http://dx.doi.org/10.13005/bbra/2172

ABSTRACT: Organophosphate compounds are the third common cause of poisoning and the main cause of death by poisoning in iran. This study has been done to analyze the effect of Intraperitoneal injection of homatropine Eye drop on acute poisoning by organophosphate poisons. This experimental study has been done on three groups of ten rats. All the rats were injected with 25 mg/kg dichlorvos poison Subcutaneously and then they were divided into three groups by random. The first group was injected with normal saline, the second group with homatropine eye drop and the third group with Atropine. All the rats were observed for 120 minutes and their Cardiovascularandrespiratoryvital signs were measured with precision. The data were analyzed using Chi-squaretest and ANOVA. The significance level was considered to be 0.05. All the rats of control group were deceased. And all the rats who received homatropine and atropine survived. There was no significant difference regarding the time period to effect and effectiveness of atropine compared to homatropine for Respiratory rate (p=0.412) and heart rate (0.635). Using homatropine eye drop Intraperitonealy can prevent the mortality of lab rats the way atropine does in case of acute poisoning with organophosphate poisons.

KEYWORDS: Organophosphate poisons; homatropine; mortality

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