Changes In Ck-Mb Level In Acute Myocardial Infarction

B. S. Dangi¹, B. K. Agrawal¹ and B. S. Yadav²

¹Department of Biochemistry and Cardiology, Gandhi Medical College, Bhopal (India). ²Department of Biochemistry, RKDF Dental College and Research Centre, Bhopal (India)

ABSTRACT: Cardiac markers (Serum proteins) are tools in diagnosis of myocardial infarction. CK-MB is most valuable cardiac marker released from the damaged heart muscles. Total 196 MI patients and 104 controls (normal subjects) were studied in Cardiology Department of Hamidia Hospital, Bhopal. Initial elevation of CK-MB occurs after 6 hours, mean time to peak elevation was 8-24 hrs and time to return to the baseline was >48 hrs. In male controls the mean CK-MB level was 19.34 ±2.83 IU/L and in female the mean CK-MB level was 19.32 ± 3.65 IU/L. The mean value of CK-MB at different time intervals in MI patients were 245.12 ± 64.56 at 8-16 hrs, 230.50 ± 44.88 IU/L at 17-24 hrs, 88.33 ± 3.84 IU/L at 25-32 hrs. 74.50 ± 38.19 IU/L at 33-40 hrs and 50.66 ± 2.32 IU/L at 41-48 hrs. The difference in CK-MB level among male and female controls was statistically insignificant.

KEYWORDS: CK-MB; Creatine Kinase MB form; MI- Myocardial infarction

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