Manuscript accepted on : May 21, 2007
Published online on: 01-02-2016
Sahoo1*, P. K. Panda1, S. R. Mishra1, A. Tripathy1 And P. Ellaiah2
1University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar -751 004 (India) 2Pharmaceutical Biotechnology Division, Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003 (India)
ABSTRACT: The inhibitory effects of some metal ions, some synthesized compounds and their derivatives with 2-aryl acenaphthimidazoles and their N-Mannich bases on optimum production of hyaluronidase was evaluated employing Streptococcus mitis MTCC *2695 and Streptococcus equi SED 9 by submerged fermentation. The maximum enzymatic activity was obtained with an initial pH (6 and 5.5), incubation temperature 37°, incubation time for 48 h and inoculum level (6 and 10 %) with inoculum age 24 h by Streptococcus mitis and Streptococcus equi SED-9 respectively. The results indicated that metals like Fe3+, Zn2+ Mn2+, Ag+, Ni2+, Sr2+ and Cu2+ acted as strong inhibitors of the enzyme. N-Mannich bases of 2-aryl acenaphthimidazoles exhibited promising inhibitory activity.
KEYWORDS: Hyaluronidase production; Streptococcus sp.
Download this article as:
| Copy the following to cite this article: Sahoo S, Panda P. K, Mishra S. R, Tripathy A, Ellaiah P. Effect of some inhibitors on hyaluronidase production by Streptococcus mitis MTCC *2695 and Streptococcus equi SED 9 species. Biosci Biotechnol Res Asia 2007;4(1) |
| Copy the following to cite this URL: Sahoo S, Panda P. K, Mishra S. R, Tripathy A, Ellaiah P. Effect of some inhibitors on hyaluronidase production by Streptococcus mitis MTCC *2695 and Streptococcus equi SED 9 species. Biosci Biotechnol Res Asia 2007;4(1). Available from: https://www.biotech-asia.org/?p=5761 |
This work is licensed under a Creative Commons Attribution 4.0 International License.
