In vitro evaluation of Atenolol tablets produced in Iran with the Atenolol tablets imported from abroad and comparison between them

A. Ashnagar¹*, N. Gharib Naseri², E. Salimi¹ and V. Nouruzi¹

¹School of Pharmacy, Ahwaz Jundi Shapour University of Medical Sciences, Ahwaz (Iran) ²Ahwaz Faculty of Petroleum Engineering, Petroleum University of Technology, Ahwaz (Iran)

ABSTRACT: In vitro evaluation on three types of atenolol tablets produced by three Iranian Pharmaceutical companies (Exir, Darou Pakhsh and Tolid Darou) and three types of atenolol tablest produced by foreign companies (Tenormin? of England, Apo-Atenolol of Canada and Hipres? of India) were carried out. Results obtained in this research have shown that tablets produced in Iran by Exir and Darou Pakhsh Pharmaceutical companies have the minimum standard limits which are acceptable by the internationally well known Pharmacopoeia such as USP, but Atenolol tablets produced by Tolid Darou company, at least in the case of releasing of active ingredient in the desired time, lacks the standard limits. The three imported types of tablets have the internationally acceptable standard limits.

KEYWORDS:

Atenolol, Tenormin?; 4 -[2'-hydroxy-3'-[(1- methylethyl) amino] propoxy]- benzeneacetamide; beta-

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