Manuscript accepted on : November 18, 2007
Published online on: 03-02-2016
B. G. Desai1, A. R. Annamalai*2, B. M. Dinesh1. and K. S. Raghu1
1K. L. E. Society’s College of Pharmacy, II block, Rajajinagr, Bangalore - 560 010 (India) 2Anamalai university, Annamalai nagar, Chidambaram, Tamilnadu (India)
ABSTRACT: The Matrix type TDDS of Lisinopril were prepared using different ratios of Ethyl cellulose (EC): Poly vinylpyrrolidone (PVP) (3:1, 2:3, 4:1, 1:2, 2:1, and 1:4) by solvent evaporation technique. Physicochemical parameters were characterized and dissolution studies of the formulated films were performed. In addition solubility studies at various pH, partition coefficient in octanol/water system, flux and enhancement ratio were also evaluated. In-vitro permeation studies were done using modified Franz diffusion cells through human cadaver skin utilizing 20%PEG 400 in normal saline. Permeation studies illustrated, 4% Hyaluronidase enzyme was a good enhancer. The prepared films were subjected to SEM and FTIR spectral analysis. Higuchi and Peppas model were used for optimizing the formulation.
KEYWORDS: Lisinopril;Transdermal Patches; PVP; EC; Permeability Study; Chemical enhancers; Optimization
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| Copy the following to cite this article: Desai B. G, Annamalai A. R, Dinesh B. M, Raghu K. S. Design and in-vitro evaluation of Lisinopril transdermal patches containing Ethylcellusose-povidone as film formers. Biosci Biotechnol Res Asia 2007;4(2) |
| Copy the following to cite this URL: Desai B. G, Annamalai A. R, Dinesh B. M, Raghu K. S. Design and in-vitro evaluation of Lisinopril transdermal patches containing Ethylcellusose-povidone as film formers. Biosci Biotechnol Res Asia 2007;4(2). Available from: https://www.biotech-asia.org/?p=6068 |
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