Effect of starch over sodium starch glycolate in dispersible tablet

Pichandy Muthuprasanna*, Uppala Mohan Kumar And Vanam Anjaneya Mithra

Department of pharmaceutics, Vels college of pharmacy, Pallavaram, Chennai - 600 117 (India)

ABSTRACT: Our work aims to find the optimum concentration of the diluent –starch with sodium starch glycolate (SSG) for the fast dispersion for the dispersible tablet. We had formulated four formulations of varying proportions of starch (0.05 %,0.1 %,0.2 % and 0.15%) with sodium starch glycolate at a concentration of 4%. The tablet were formulated with SSG in relation to that of starch and evaluating their physical characteristics such as hardness , weight variation and their disintegrating efficiency. The fast dispersible tablets with an acceptable hardness and desirable taste could be prepared within the optimum starch concentration. The formulation and its characterization of the dispersible tablets showed that the formulation A (0.05 %) of starch gave a faster dispersibility than the other formulation including the market sample. Hardness due to compaction force plays a vital role in the dispersion of the tablet. Thus a concentration of 0.05 % of starch would be optimum at a hardness of 1.6 kg/cm2 would be optimum to have a faster disintegration time.

KEYWORDS: Sodium starch glycolate; dispersible tablet; starch; compaction

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