Manuscript accepted on : October 07, 2007
Published online on: 05-02-2016
Saba K. and P. Umadevi
Department of Research, Jawaharlal Nehue Cancer Hospital and Research Centre, Idgah Hills, Bhopal - 462 001 (India)
ABSTRACT: Diclofenac sodium belongs to the non steroidal anti inflammatory drugs (NSAIDS) and more especially to the phenyl acetic acid derivative. NSAIDS have been clinically used for their anti-inflammatory antipyretic & analgesic properties. It is widely believed that their therapeutic action is based on their ability to block the product of prostaglandin by their inhibitory effect against cyclo-oxygenate. The present study is based on hematological and histological toxicity presented by the use of NSAIDS (diclofenac). The present study has demonstrated that even a small dose of 0.1mg per kg body weight diclofenac orally can induce noticeable decrease in the blood parameter especially in RBC & Hemoglobin count. Intestinal mucosa has also shown histopathological changes and decrease in the number of crypts per circumference.
KEYWORDS: NSAIDS; (Non steroidal anti inflammatory drug); prostaglandin; crypt cells; cyclo-oxygenate
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| Copy the following to cite this article: Saba K, Umadevi P. Hematological and histopathological behavior of Swiss albino mice against different dosage of diclofenac sodium. Biosci Biotechnol Res Asia 2007;4(2) |
| Copy the following to cite this URL: Saba K, Umadevi P. Hematological and histopathological behavior of Swiss albino mice against different dosage of diclofenac sodium. Biosci Biotechnol Res Asia 2007;4(2). Available from: https://www.biotech-asia.org/?p=6281 |
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